The U.S. is anticipated to witness a surge in product demand over the forecast period owing to the growing demand for low-calorie foods and ingredients. Moreover, the rising awareness about the natural products that play a key role in general health management is further accelerating the product demand in the U.S. Xylitol market. The U.S. is among the leading producing countries of xylitol. The producers have been targeting various potential application industries, such as nutraceutical and cosmetics & personal care, to strengthen the market positions in the U.S. market. In the enzymatic process, different microorganisms like yeast, bacteria, and fungi are used, which helps in a sustainable environment. Due to a low glycemic index sweetener, it is being used as a food additive in confectionery, bakery, drinks, and dairy products as well as in the nutraceutical and pharmaceutical industries. The most commonly used raw materials for the commercial production of xylose are corn cobs and birch barks. The production of xylose from corn cob is less expensive and thus the price of xylitol sourced from corn cob is lower than that of the one derived from the birch trees.